There are a number of file formats that are supported in Pixillion. These formats are as follows:
| Format | Extensions | Windows | Mac OS X | Pixillion Plus Required | Notes |
| Adobe Photoshop Document | *.psd | Read & Write | Read & Write | Yes | Layers are not maintained. |
| Adobe Photoshop Large Document file | *.psb | Read | - | - | Layers are not maintained. |
| Adobe Portable Format | Read & Write | Read & Write | - | - | |
| Adobe Illustrator Format | *.ai | Read | Read | Yes | Use thumbnail if not PDF compatible file |
| Apple AAE sidecar file | *.aae | Read | Read | - | Read the JPEG file corresponding to AAE |
| AVID TARGA | *.tga | Read & Write | Read & Write (10.5 and above) | - | - |
| AV1 Image Format | *.avif | Read & Write | - | - | - |
| DjVu | *.djvu | Read | - | - | - |
| Direct Draw Surface | *.dds | Read | - | - | - |
| Encapsulated PostScript | *.eps | Write | - | - | - |
| Graphics Interchange Format | *.gif | Read & Write | Read & Write | - | - |
| High Efficiency Image File Format | *.heic *.heif | Read & Write | Read | - | Support only still images. |
| Joint Photographic Experts Group | *.jpeg;*.jpg | Read & Write | Read & Write | - | - |
| JPEG File Interchange Format | *.jfif | Read | Read | - | Read as JPEG file |
| Joint Photographic Experts Group 2000 | *.jp2 | Read & Write | Read & Write | - | - |
| JPEG Stereoscopic | *.jps | Read | Read | Yes | - |
| JPEG Extended Range | *.wdp;*.hdp;*.jxr | Read & Write | - | - | Also known as Microsoft HD Photo or Windows Media Photo. |
| Maya Image File Format | *.iff | Read & Write | Read & Write | - | Z-Buffer is not maintained. |
| Windows Document | *.docx | Write | Write | - | - |
| Microsoft Bitmap | *.bmp;*.dib;*.rl4;*.rl8 | Read & Write | Read & Write | - | Only read for *rl4 and *.rl8 |
| Microsoft Icon | *.ico | Read & Write | Read Write (10.5 and above) | - | - |
| MPO | *.mpo | Read | Read | Yes | - |
| OpenEXR | *.exr | Read | - | - | - |
| Personal Computer eXchange | *.pcx | Read & Write | Read & Write | - | - |
| Portable Network Graphics | *.png | Read & Write | Read & Write | - | - |
| Portable Pixmap | *.pbm;*.pgm;*.ppm;*.pnm | Read & Write | Read & Write | Yes | - |
| Progressive Graphics File | *.pgf | Read & Write | Read & Write | Yes | - |
| Raw Camera Output | *.arw;*.cr2;*.cr3;*.crw; *.dcr;*.dng;*.erf;*.kdc; *.mef;*.mos;*.mrw;*.nef; *.nrw;*.orf;*.pef;*.ptx; *.r3d;*.raf;*.raw;*.rw2; *.sr2;*.srf;*.srw;*.x3f | Read | Read | - | - |
| Sun Raster | *.ras | Read & Write | Read & Write | Yes | - |
| SVG | *.svg;*.svgz | Read & Write | Read & Write | - | Masking is not maintained |
| Tagged Image File Format | *.tiff;*.tif | Read & Write | Read & Write | - | - |
| WebP | *.webp | Read & Write | Read & Write (10.5 and above) | Yes | Also support animated WebP |
| Windows Metafile | *.wmf;*.emf;*.emz | Read & Write | - | - | - |
| Wireless Bitmap | *.wbmp | Read & Write | Read & Write | Yes | - |
| eXperimental Computing Facility | *.xcf | Read | - | - | - |